DNA/RNA Synthesis Activator

DNA/RNA Synthesis Activators (23):

Cat. No.	Product Name	Effect	Purity

HY-112980

Nusinersen	Activator	98.91%
Nusinersen is an antisense oligonucleotide agent that modifies pre–messenger RNA splicing of the SMN2 gene and thus promotes increased production of full-length SMN protein.

HY-W010832

Uridine-5'-diphosphate disodium salt	Activator	≥99.0%
Uridine-5'-diphosphate disodium salt is a potent, selective P2Y₆ receptor native agonist (EC₅₀=300 nM; pEC₅₀=6.52 for human P2Y₆ receptor). Uridine-5'-diphosphate disodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis.

HY-101400A

Deoxycytidine triphosphate trisodium salt	Activator	99.46%
Deoxycytidine triphosphate trisodium salt (dCTP trisodium salt) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate trisodium salt has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.

HY-135218A

AV-153 free base	Activator	99.65%
AV-153 free base, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 free base intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 free base interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 free base has anti-cancer activity.

HY-138597

5'-O-TBDMS-dT	Activator	99.43%
5'-O-TBDMS-dT is a nucleoside with protective and modification effects.

HY-138586

DMT-dC(ac) Phosphoramidite	Activator	99.76%
DMT-dC(ac) Phosphoramidite is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis.

HY-138603

5'-O-DMT-N4-Bz-2'-F-dC	Activator	99.85%
5'-O-DMT-N4-Bz-2'-F-dC is a nucleoside with protective and modification effects.

HY-138579

2'-OMe-G(ibu) Phosphoramidite	Activator	99.42%
2'-OMe-G(ibu) Phosphoramidite is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis.

HY-101400

Deoxycytidine triphosphate	Activator	98.15%
Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.

HY-138595

5'-O-TBDMS-Bz-dA	Activator	98.37%
5'-O-TBDMS-Bz-dA is a nucleoside with protective and modification effects.

HY-112060

Saccharin 1-methylimidazole	Activator	98.66%
Saccharin 1-methylimidazole is an activator for DNA/RNA Synthesis.

HY-101400S3

Deoxycytidine triphosphate-¹⁵N₃ dilithium	Activator	≥99.0%
Deoxycytidine triphosphate-¹⁵N₃ (dCTP-¹⁵N₃ dilithium; 2′-Deoxycytidine-5′-triphosphate-¹⁵N₃) dilithium is ¹⁵N labeled Deoxycytidine triphosphate (HY-101400). Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.

HY-138578

2'-O-Me-C(Bz) Phosphoramidite	Activator	99.05%
2'-O-Me-C(Bz) Phosphoramidite is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis.

HY-138580

2'-OMe-A(Bz) Phosphoramidite	Activator	99.74%
2'-OMe-A(Bz) Phosphoramidite is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis.

HY-101400S4

Deoxycytidine triphosphate-¹³C₉ dilithium	Activator
Deoxycytidine triphosphate-¹³C₉ (dCTP-¹³C₉ dilithium; 2′-Deoxycytidine-5′-triphosphate-¹³C₉) dilithium is ¹³C-labeled Deoxycytidine triphosphate (HY-101400). Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.

HY-168556

YJ9069	Activator
YJ9069 is a selective CDK12/CDK13 PROTAC degrader with an IC₅₀ of 22.22 nM for in VCaP cells. CDK12/13 degradation rapidly triggers gene-length-dependent transcriptional elongation defects, leading to DNA damage and cell-cycle arrest. YJ9069 effectively inhibits proliferation in subsets of prostate cancer cells and significantly suppresses prostate tumor growth. (Pink: CDK12/CDK13 degradation agent (HY-168658); Black: Linker (HY-W015967); Blue: ligand for E3 ligase (HY-103596)).

HY-101400S2

Deoxycytidine triphosphate-¹³C₉,¹⁵N₃ dilithium	Activator
Deoxycytidine triphosphate-¹³C₉,¹⁵N₃ (dCTP-¹³C₉,¹⁵N₃ dilithium; 2′-Deoxycytidine-5′-triphosphate-¹³C₉,¹⁵N₃) dilithium is ¹³C and ¹⁵N-labeled Deoxycytidine triphosphate (HY-101400). Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.

HY-W010820

Uridine 5'-diphosphate sodium salt	Activator
Uridine 5'-diphosphate sodium salt is a potent, selective P2Y₆ receptor native agonist (EC₅₀=300 nM; pEC₅₀=6.52) and a potent P2Y₁₄ antagonist (pEC₅₀=7.28). Uridine 5'-diphosphate sodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis.

HY-135218

AV-153	Activator
AV-153, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 has anti-cancer activity.

HY-101400S

Deoxycytidine triphosphate-d₁₄ dilithium	Activator
Deoxycytidine triphosphate-d₁₄ (dCTP-d₁₄ dilithium; 2′-Deoxycytidine-5′-triphosphate-d₁₄) dilithium is deuterium labeled Deoxycytidine triphosphate (HY-101400). Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.

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