2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. DNA/RNA Synthesis
  5. DNA/RNA Synthesis Activator

DNA/RNA Synthesis Activator

DNA/RNA Synthesis Activators (30):

Cat. No. Product Name Effect Purity
  • HY-W010832
    Uridine-5'-diphosphate disodium salt
    		Activator 99.23%
    Uridine-5'-diphosphate disodium salt is a potent, selective P2Y6 receptor native agonist (EC50=300 nM; pEC50=6.52 for human P2Y6 receptor). Uridine-5'-diphosphate disodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis.
  • HY-112980
    Nusinersen
    		Activator 98.91%
    Nusinersen is an antisense oligonucleotide active molecule. Nusinersen modifies the pre-messenger RNA splicing of the SMN2 gene, thereby promoting the production of full-length SMN protein. Nusinersen improves spinal muscular atrophy.
  • HY-147313
    TH10785
    		Activator 99.93%
    TH10785 is a DNA glycosylase 1 (OGG1) activator, TH10785 can interact with the phenylalanine-319 and glycine-42 amino acids of OGG1 and increase the enzyme activity, generates β, δ-lyase enzymatic function. TH10785 can control the catalytic activity mediated by a nitrogen base within its molecular structure. TH10785 can be used for the research of various diseases and aging connected with DNA oxidative lesions.
  • HY-172085
    SH514
    		Activator 99.94%
    SH514 is an orally active IRF4 inhibitor (IC50 = 2.63 μM). SH514 binds to the IRF4-DBD domain, thereby inhibiting the interaction of IRF4 protein with DNA (KD = 1.28 μM). SH514 can inhibit the proliferation of IRF4-high-expressing NCI-H929 and MM.1R cells, and displays no cytotoxicity for normal cells. SH514 significantly downregulates the expression of IRF4 downstream target genes concentration-dependently. SH514 inhibits the expression of cell cycle-related proteins CDC2, Cyclin B1, Cyclin D1, Cyclin E1, and CMYC in Multiple Myeloma cells. SH514 can induce DNA damage and increase the expression of γH2AX. SH514 effectively inhibits the proliferation of multiple myeloma tumors .
  • HY-101400A
    Deoxycytidine triphosphate (trisodium) solution (100mM)
    		Activator 99.46%
    Deoxycytidine triphosphate trisodium (dCTP trisodium) solution (100mM) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate trisodium salt has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.
  • HY-138580
    2'-OMe-A(Bz) Phosphoramidite
    		Activator 99.74%
    2'-OMe-A(Bz) Phosphoramidite is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis.
  • HY-W010820
    Uridine 5'-diphosphate sodium salt
    		Activator 98.0%
    Uridine 5'-diphosphate sodium salt is a potent, selective P2Y6 receptor native agonist (EC50=300 nM; pEC50=6.52) and a potent P2Y14 antagonist (pEC50=7.28). Uridine 5'-diphosphate sodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis.
  • HY-138597
    5'-O-TBDMS-dT
    		Activator 99.43%
    5'-O-TBDMS-dT is a nucleoside with protective and modification effects.
  • HY-138586
    DMT-dC(ac) Phosphoramidite
    		Activator 99.76%
    DMT-dC(ac) Phosphoramidite (compound 30f) is a phosphoramidite derivative that can be used for the oligonucleotide synthesis.
  • HY-135218A
    AV-153 free base
    		Activator 99.65%
    AV-153 free base, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 free base intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 free base interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 free base has anti-cancer activity.
  • HY-138603
    5'-O-DMT-N4-Bz-2'-F-dC
    		Activator 99.85%
    5'-O-DMT-N4-Bz-2'-F-dC is a nucleoside with protective and modification effects.
  • HY-174216
    PZL-A
    		Activator 99.72%
    PZL-A is a activator of mitochondrial DNA (mtDNA) synthesis. PZL-A restores wild-type-like activity to mutant forms of polymerase γ (POLγ) with AC50 s of 160 and 20 nM for A467T and G848S. PZL-A activates mtDNA synthesis in cells, enhancing biogenesis of the oxidative phosphorylation machinery and cellular respiration. PZL-A is promising for relieving POLG disease and other severe conditions linked to depletion of mtDNA.
  • HY-151224
    Thermospermine
    		Activator 99.90%
    Thermospermine, a structural isomer of Spermine, is synthesized by a thermospermine synthase designated ACAULIS5 (ACL5). Thermospermine suppresses auxin-inducible xylem differentiation in Arabidopsis thaliana.
  • HY-101400S3
    Deoxycytidine triphosphate-15N3 dilithium
    		Activator 99.0%
    Deoxycytidine triphosphate-15N3 (dCTP-15N3 dilithium; 2′-Deoxycytidine-5′-triphosphate-15N3) dilithium is 15N labeled Deoxycytidine triphosphate (HY-101400). Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.
  • HY-168556
    YJ9069
    		Activator
    YJ9069 is a selective CDK12/CDK13 PROTAC degrader with an IC50 of 22.22 nM for in VCaP cells. CDK12/13 degradation rapidly triggers gene-length-dependent transcriptional elongation defects, leading to DNA damage and cell-cycle arrest. YJ9069 effectively inhibits proliferation in subsets of prostate cancer cells and significantly suppresses prostate tumor growth. (Pink: CDK12/CDK13 degradation agent (HY-168658); Black: Linker (HY-W015967); Blue: ligand for E3 ligase (HY-103596)).
  • HY-138595
    5'-O-TBDMS-Bz-dA
    		Activator 98.37%
    5'-O-TBDMS-Bz-dA is a nucleoside with protective and modification effects.
  • HY-112060
    Saccharin 1-methylimidazole
    		Activator 98.66%
    Saccharin 1-methylimidazole is an activator for DNA/RNA Synthesis.
  • HY-138578
    2'-O-Me-C(Bz) Phosphoramidite
    		Activator 99.05%
    2'-O-Me-C(Bz) Phosphoramidite is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis.
  • HY-101400S4
    Deoxycytidine triphosphate-13C9 dilithium
    		Activator
    Deoxycytidine triphosphate-13C9 (dCTP-13C9 dilithium; 2′-Deoxycytidine-5′-triphosphate-13C9) dilithium is 13C-labeled Deoxycytidine triphosphate (HY-101400). Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.
  • HY-101400S2
    Deoxycytidine triphosphate-13C9,15N3 dilithium
    		Activator
    Deoxycytidine triphosphate-13C9,15N3 (dCTP-13C9,15N3 dilithium; 2′-Deoxycytidine-5′-triphosphate-13C9,15N3) dilithium is 13C and 15N-labeled Deoxycytidine triphosphate (HY-101400). Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.